在患有复发性复发性硬化症患者的认知现象的纵向研究
Cláudia Sousa1,2,3, Márcia França3, Teresa Jacques2
1Department of Neurology, ULS São João Porto, EPE, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
概括
多发性硬化症 (MS) 患者的认知障碍随着时间的推移而有所改善,越来越少的人经历多领域缺陷. 早期的视神经炎与较高的认知障碍率有关.
科学领域:
- 神经科学是一个神经科学.
- 临床神经学 临床神经学
- 认知科学 认知科学
背景情况:
- 认知功能障碍是复发性复发性多发性硬化症 (RRMS) 的一个重大挑战.
- 了解认知表型的纵向轨迹对于有效管理至关重要.
研究的目的:
- 研究成年RRMS患者随着时间的推移而发生的认知表型的演变.
- 确定人口和临床因素是否影响MS认知衰退的进展.
主要方法:
- 125名RRMS患者使用BRBN-T和BICAMS进行了3-5年的年度神经心理评估.
- 使用多发性硬化症认知障碍国际分类 (IC-CoDiMS) 定义认知表型.
主要成果:
- 认知障碍的患病率在3年内下降 (BRBN-T:29.6%至18.5%;BICAMS:33.6%至19.2%).
- 大多数认知测试都显示了随着时间的推移的改善,除了口语流.
- 通过第4/5次评估解决的多领域认知障碍.
- 患有视神经炎作为发病综合征的患者表现出更高的认知障碍.
结论:
- 在RRMS患者的认知表现可以纵向改善.
- 监测认知进化是制定有针对性的干预措施的关键.
- 预防认知衰退可以提高MS患者的生活质量.
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