在儿童患者的骨矿物密度缺陷的机会性查从腹部计算机断层扫描获得的其他迹象:一个横截面研究
Chuan Liu1, Dandan Yang2, Xijian Chen1
1Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.
Pediatric radiology
|February 18, 2025
概括
定量计算断层扫描 (QCT) 可以选儿科患者的低骨矿物质密度 (BMD). 患有癌症,脏疾病或特定病史的儿童有更高的BMD缺陷风险.
科学领域:
- 儿科放射学 儿科放射学
- 骨的新陈代谢 骨的新陈代谢
- 医疗成像医学成像
背景情况:
- 定量计算断层扫描 (QCT) 是为成人骨质疏松症查而建立的.
- 儿童群体中QCT的应用是有限的.
- 儿童的机会性查是一个新兴的领域.
研究的目的:
- 评估QCT用于儿科患者机会性骨矿物密度 (BMD) 查的可行性.
- 确定在接受腹部CT扫描的儿童的腰椎骨质量缺陷的患病率.
- 在这个儿科队列中确定与低BMD相关的危险因素.
主要方法:
- 748名儿科患者的回顾性横截面研究 (2018年10月 - 2020年11月).
- 使用QCT评估的腰椎椎骨矿物质密度 (BMD).
- 统计分析包括签名等级测试和后勤回归来确定风险因素.
主要成果:
- 在11.5% (86/748) 的儿科患者中检测到腰部下部骨髓瘤 (Z-score ≤ -2).
- 与低BMD的显著关联包括化学疗法/放射治疗史,慢性皮质类固醇暴露,年龄较大和身高较低.
- 化疗/辐射和皮质类固醇暴露显示出最强的关联 (P < 0.001).
结论:
- QCT是一种可行的方法,用于在儿科患者中机会性查低BMD.
- 患有癌症,病或有化疗,放射治疗或皮质类固醇治疗史的儿童是BMD损失的高风险人群.
- 通过QCT早期识别低BMD,可以为有风险的儿童提供有针对性的干预措施.
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