Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Neural Regulation01:37

Neural Regulation

39.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.1K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

429
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
429

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Analysis of expression and prognostic significance of vimentin and the response to temozolomide in glioma patients.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine·2016
Same author

Missing Messages of Clinical Pharmacologic Survey on Inotropic Drug Use in Neonatal Critical Care.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2016
Same author

Activin pathway enhances colorectal cancer stem cell self-renew and tumor progression.

Biochemical and biophysical research communications·2016
Same author

Clinical outcome of endoscopic covered metal stenting for resolution of benign biliary stricture: Systematic review and meta-analysis.

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society·2016
Same author

MicroRNA 182 inhibits CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup> Treg differentiation in experimental autoimmune encephalomyelitis.

Clinical immunology (Orlando, Fla.)·2016
Same author

Lymphoma and inflammation in the orbit: Diagnostic performance with diffusion-weighted imaging and dynamic contrast-enhanced MRI.

Journal of magnetic resonance imaging : JMRI·2016

相关实验视频

Updated: May 27, 2025

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.1K

基于放射学的建模揭示了大脑小脑参与帕金森病的情况.

Yini Chen1,2, Yiwei Qi2, Yiying Hu1,3

  • 1Key Laboratory of Liaoning Province for Research on the Pathogenic Mechanisms of Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, 116021, China.

Cerebellum (London, England)
|February 18, 2025
PubMed
概括

小脑的磁共振成像 (MRI) 放射学可以区分帕金森病 (PD) 患者与健康个体. 这项研究强调小脑在PD中的作用及其作为成像生物标志物的潜力.

关键词:
大脑小部分的大脑小部分磁共振成像是一种磁共振成像技术.帕金森氏症 帕金森氏症无线电学 (Radiomics) 是一种放射学.

更多相关视频

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

15.6K
A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
11:50

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging

Published on: February 4, 2022

3.9K

相关实验视频

Last Updated: May 27, 2025

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.1K
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

15.6K
A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
11:50

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging

Published on: February 4, 2022

3.9K

科学领域:

  • 神经成像是一种神经成像.
  • 无线电学 (Radiomics) 是一种放射学.
  • 生物标志物发现发现

背景情况:

  • 新出现的证据表明小脑与帕金森病 (PD) 的病理生理学有关.
  • 脑小区功能障碍在神经退行性疾病中越来越被认可.

研究的目的:

  • 调查小脑磁共振成像 (MRI) 放射学对区分PD患者与健康对照 (HC) 的实用性.
  • 为了确定与小脑中PD相关的关键放射性特征.

主要方法:

  • 从374名参与者 (PPMI和内部队列) 的3D-T1MRI数据的回顾性分析.
  • 从小脑灰色和白质中提取883个放射性特征.
  • 开发和评估机器学习模型 (灰质,白质,组合) 用于PD分类.

主要成果:

  • 灰色和白色物质的联合放射学模型获得了最高的性能,在训练组中,ROC曲线下的面积 (AUC) 为0.936,在测试组中为0.881.
  • 大脑小脑灰质模型:AUC为0.931 (训练) 和0.874 (测试).
  • 小脑白质模型:AUC为0.846 (训练) 和0.868 (测试).
  • 关键特征包括灰色级依赖矩阵,灰色级共发生矩阵,第一顺序 (灰色物质) 和灰色级大小区域矩阵 (白色物质).

结论:

  • 脑小叶MRI放射学有效地区分了PD患者与HC患者.
  • 这些发现支持小脑在PD中的重要作用.
  • 脑小叶放射学显示出作为帕金森病新型成像生物标记物的前景.