在癌症患者中,肺栓塞相关的死亡率
Marco Zuin1,2, Anju Nohria3, Stanislav Henkin4
1Department of Translational Medicine, University of Ferrara, Ferrara, Italy.
JAMA network open
|February 18, 2025
概括
尽管癌症死亡率下降,但美国癌症患者的年龄调整肺栓塞 (PE) 死亡率在2011-2020年期间上升. 这一趋势在年轻人和特定的人口群体中尤其令人担忧.
科学领域:
- 在瘤学瘤学.
- 心血管医学 心血管医学
- 公共卫生 公共卫生
背景情况:
- 急性肺栓塞 (PE) 是癌症患者死亡的重要原因.
- 了解PE相关死亡率的趋势对于改善患者的治疗结果至关重要.
研究的目的:
- 分析2011年至2020年美国癌症患者中PE相关死亡率的趋势.
- 检查各种人口和地理子组的这些趋势.
主要方法:
- 一项使用CDC流行病学研究 (WONDER) 数据库的广泛在线数据的队列研究.
- 对15岁以上癌症患者的PE年龄调整死亡率 (AAMR) 的分析.
- 加入点回归建模来评估趋势和平均年均百分比变化 (AAPC).
主要成果:
- 癌症患者的PE相关死亡率AAMR每年增加2.5% (2011-2020年).
- 在年轻的成年人 (15-64岁),特定的种族/种族群体和美国南部地区观察到增加.
- 癌症发病率和死亡率下降,但癌症诊断和死亡的绝对数量上升.
结论:
- 根据年龄调整的PE相关死亡率在美国癌症患者中增加,尽管癌症死亡率下降.
- 在年轻人和特定人群中PE死亡率的上升需要进一步调查.
- 结果可以指导研究PE预防和治疗在癌症护理.
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