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Updated: May 27, 2025

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
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在星球细胞中异常的ERK信号破坏了与RASopathy相关的BRAF突变小鼠模型中的学习和记忆

Minkyung Kang1,2, Jihye Choi3, Jeongho Han4

  • 1Department of Physiology, and.

The Journal of clinical investigation
|February 18, 2025
PubMed
概括

神经干细胞中的功能获取BRAF突变通过破坏星细胞功能和信号传递导致记忆缺陷. 准天体细胞中的ERK活动可以在RAS病变中拯救这些认知障碍.

关键词:
发展发展发展 发展发展遗传性疾病是一种遗传性疾病.智力障碍 智力障碍是一种智力障碍.神经发育 神经发育神经科学是一个神经科学.

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The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
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