预后营养指数和结石患病率之间的反向关联:基于人口的研究
Lei Wang1, Yi Yu1, Ziwen Jiang2
1The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine, Foshan, Guangdong, China.
PloS one
|February 18, 2025
概括
预后营养指数 (PNI) 与美国成年人结石风险较低有关. 这种反向关联在男性和高胆固醇水平的个体中特别强烈.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 结石很常见,受代谢问题,饮食和生活方式的影响.
- 预后营养指数 (PNI) 反映了营养状况,可能与结石风险相关.
- 这项研究调查了美国成年人群中PNI和结石患病率之间的关联.
研究的目的:
- 检查预后营养指数 (PNI) 与结石患病率之间的关系.
- 为了确定特定的子组,如男性或高胆固醇患者,这种关联可能更明显.
主要方法:
- 利用了来自国家健康和营养检查调查 (2009-2018) 的数据.
- 采用多变量逻辑回归和子组分析来评估独立的协会.
- 使用光滑曲线探索非线性关联和值效应.
主要成果:
- 包括13,835名参与者;8.48%患有结石.
- 发现PNI和结石患病率之间的反向关联 (OR=0.97,P<0.001).
- 这种联系在男性和总胆固醇≥5.2mmol/L的个体中是显著的,特别是在PNI转折点57以下.
结论:
- PNI与结石风险有负面关联.
- 反向关系在男性和高胆固醇患者中更为明显.
- 量身定制的营养干预措施可能对高风险子组有益.
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