细胞遗传异常和高风险疾病在新诊断和复发/逆转多发性髓瘤中同时发生
Martin F Kaiser1,2, Pieter Sonneveld3, David A Cairns4
1The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom.
概括
多发性骨髓瘤 (MM) 的高风险细胞遗传异常 (HRCAs) 始终预测不良结果. 患有两个或两个以上HRCA的患者面临着最糟糕的预后,指导针对未满足需求的向治疗的开发.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
背景情况:
- 多发性骨髓瘤 (MM) 结局是异质的,尽管生存率有所改善.
- 准确识别高风险MM对于患者护理至关重要.
- 高风险细胞遗传异常 (HRCAs) 是关键的预后指标.
研究的目的:
- 评估HRCA同时发生与新诊断的 (NDMM) 和复发/耐药MM (RRMM) 的预后的一致性.
- 为了评估HRCA在不同治疗方式之间的关联.
- 调查单个与多个HRCAs的预后影响.
主要方法:
- 随机对照试验 (2000-2021) 报告HRCA测试的系统审查.
- 使用中央算法对单 (一个HRCA) 和双 (≥两个HRCAs) 匹配的试验数据进行联合分析.
- 对无进展生存期 (PFS) 和总生存期 (OS) 的危险比率 (HR) 的元分析.
主要成果:
- 分析了24项试验 (13,926名患者).
- ≥两个HRCAs显著恶化了PFS (HR=2.28) 和OS (HR=2.94).
- 一个HRCA还影响了PFS (HR=1.51) 和OS (HR=1.69),最近的研究和MM亚型的研究结果一致.
结论:
- 多个HRCA (≥2个) 的存在与NDMM和RRMM的最差结果密切相关.
- 这一跨治疗方法的一致发现验证了HRCA作为风险分层的关键标志物.
- 结果支持针对MM患者的新型治疗方法的专注开发,MM患者的高未满足需求是由HRCAs确定的.
更多相关视频
10:04Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
13.0K
09:41An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
8.6K
相关概念视频
Abnormal Proliferation
4.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.4K
Induced Pluripotent Stem Cells
3.9K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
3.9K
Differentiation of Common Myeloid Progenitor Cells
3.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.2K
Cancers Originate from Somatic Mutations in a Single Cell
11.4K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
11.4K
Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
