在基于人口的前性队列研究中,循环脂肪酸概况对总体影响,心血管疾病和癌症死亡率产生影响
Xiaohui Liu1, Yang Ao1, Yin Li1
1Department of Endocrinology, The Second Affiliated Hospital, Department of Nutrition, School of Public Health, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China.
Clinical nutrition (Edinburgh, Scotland)
|February 18, 2025
概括
摄入多不和脂肪酸 (PUFA),特别是n-3 PUFA和酸 (LA) 的较高摄入量与慢性疾病死亡率的降低有关. 炎症和脂质代谢部分解释了这些保护作用.
科学领域:
- 营养流行病学 营养流行病学
- 生物标志物 生物标志物
- 慢性疾病死亡率 慢性疾病死亡率
背景情况:
- 有限且不一致的证据表明,循环脂肪酸与与年龄相关的慢性疾病的死亡率之间存在联系.
- 研究血FA与总体,心血管疾病 (CVD) 和癌症死亡率的关联对于公共卫生至关重要.
- 了解潜在的潜在机制是制定有针对性的干预措施的关键.
研究的目的:
- 研究血脂肪酸与总体,心血管疾病 (CVD) 和癌症死亡率的关联.
- 探索潜在的调解机制,包括炎症和脂质代谢.
- 检查改变这些关联的潜在遗传相互作用.
主要方法:
- 来自英国生物银行的117,871名个体的前性队列研究.
- 基于高通量NMR的代谢平台,用于测量循环中的FA.
- 从死亡证明 (ICD-10代码) 收集的死亡数据,平均随访时间为11.9年.
主要成果:
- 和血脂肪酸 (SFAs) 与总死亡风险有积极的关联.
- 血多不和脂肪酸 (PUFA),包括酸 (LA) 和n-3PUFA,与总,心血管疾病和癌症死亡率相反相关.
- 循环中的非LAn-6PUFA与总和癌症死亡风险的增加有关,由C-反应蛋白 (CRP) 和阿波利波蛋白A (ApoA) 显著调解.
- 遗传变异 (rs16966952,rs174547) 改变了PUFA和死亡率之间的关联.
结论:
- 循环中的PUFA,特别是n-3PUFA和LA,与慢性疾病的过早死亡相反,促进长寿.
- 炎症途径和脂质代谢部分介导这些保护性关联.
- 遗传因素与FA相互作用,影响死亡风险,突出了个性化的营养方法.
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