社会经济地位与腹患病率之间的关系
Lauren Colquitt1, Sathyaprasad Burjonrappa2
1Rutgers RWJMS, Clinical Academic Building, 125 Paterson St, New Brunswick, NJ 08901, USA.
Journal of pediatric surgery
|February 18, 2025
概括
较低的家庭收入中位数和美国南部地区与较高的脊髓发病率相关. 表观遗传学可以解释社会经济地位和先天性形之间的这种联系. 需要进一步的研究.
科学领域:
- 医学研究 医学研究
- 儿科卫生健康 儿科卫生健康
- 公共卫生 公共卫生
背景情况:
- 奥姆法洛塞尔是一种先天性形,其病因不明,但与染色体异常有关.
- 孕产妇肥胖,糖尿病和非洲裔美国人种族被确定为危险因素,这表明健康的社会决定因素.
- 这项研究调查了骨的社会经济因素,并将表观遗传学视为潜在的机制.
研究的目的:
- 为了调查被诊断为omphalocele的患者的社会经济特征.
- 探索家庭收入中位数 (MHI),种族,性别和地理区域与腹发病率之间的关联.
- 考虑表观遗传学作为一个潜在的促进者,在囊的表现.
主要方法:
- 一项采用2019年国家儿童住院患者数据库数据的横截面研究.
- 分析了大约1400个数据点,用于诊断为腹的患者.
- 使用奇方位分析来检查MHI,种族,性别和医院区域,p值值为<0.05.
主要成果:
- 在MHI四分位数,种族,性别和医院地区之间发现了囊发病率的显著差异.
- 最低的MHI四分位数 (1-47,999美元) 占患者的37% (p < 0.001).
- 南部地区的发病率最高 (45.2%,p < 0.001),较低的MHI与较高的脊髓率之间有显著的关联.
结论:
- 这项研究是首次证明MHI下部与南部地理区域之间存在关联,其中OMPHALOCELE发病率增加.
- 需要进一步的研究来阐明社会经济地位和腹发育之间的联系.
- 表观遗传学被提出为一种潜在的机制,将社会经济因素与囊的表现联系起来.
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