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伊马替尼通过JNK/Runx2通路加剧了压力过载引起的右心室衰竭

Xiaohui Zeng1, Zhuoji Ma1, Shanshan Wen2

  • 1State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

British journal of pharmacology
|February 18, 2025
PubMed
概括

伊马替尼 (imatinib) 通过激活JNK/Runx2通路,使肺高血压 (PH) 的右心室 (RV) 衰竭恶化. 抑制JNK可以改善意马替尼.

关键词:
在JNK路径中.伊马替尼布 (Imatinib) 的使用情况肺动脉带带的形成肺高血压是一种肺高血压.右心力衰竭是什么意思

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