[高风险人群中的肺结节与肺癌风险之间的关联]
1Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
|February 18, 2025
概括
在高风险人群中检测到的肺结节在癌症风险上有所不同. 部分固体结节构成最高风险,其次是纯地玻璃结节,需要有针对性的查和管理策略.
科学领域:
- 肺部医学 肺部医学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 肺结节是低剂量CT (LDCT) 查中的常见发现.
- 识别与肺癌风险相关的结节类型对于早期检测和管理至关重要.
研究的目的:
- 调查不同类型的肺结节与肺癌风险之间的关联.
- 在高风险人群中建立一个流行病学基础来管理肺结节.
主要方法:
- 一组28,539名高危人群接受了LDCT查.
- 被试被分为以下几组:没有结节,固体结节,纯地玻璃结节和部分固体结节.
- 考克斯比例危险回归模型分析了结节类型和新肺癌诊断之间的关联,平均随访时间为3.4年.
主要成果:
- 结核 (≥3毫米) 的检测率为76.5%,最常见的是固体结核 (53.7%).
- 与固体结节相比,部分固体结节的肺癌风险最高 (HR 6.49),其次是纯地玻璃结节 (HR 1.89).
- 亚组分析显示,老年人患有固体结节或先前肺部疾病的风险较高,部分固体结节的性别特异性风险较高.
结论:
- 纯地玻璃和部分固体结节与高风险查人群的肺癌风险显著增加有关.
- 对于有固体结节或先前肺部疾病的老年人,以及部分固体结节的女性患者,建议每年进行一次随访.
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