长效可逆避孕药的使用时间延长:系统性审查
Edith Guilbert1, Hélène Arguin2, Mathieu Bélanger3
1Associate Clinical Professor in the Department of Obstetrics, Gynecology and Reproduction at Laval University in Quebec and Medical Advisor at the Institut national de santé publique du Québec (INSPQ).
Canadian family physician Medecin de famille canadien
|February 18, 2025
概括
长期使用长效可逆避孕药 (LARCs),如乙格斯特勒植入物和格斯特勒/铜IUD,对于避孕是安全且非常有效的. 这种方法提供了一个可靠的选择,特别是对于那些医疗保健机会有限的人来说.
科学领域:
- 生殖健康 生殖健康
- 避孕药是一种避孕药,用于避孕.
- 公共卫生 公共卫生
背景情况:
- 长效可逆避孕药 (LARC) 是一种非常有效的避孕方法.
- 对LARCs存在处方限制,但延长使用可能会带来好处.
- 了解长期使用LARC的安全性和有效性对于计划生育至关重要.
研究的目的:
- 为了评估延长使用etonogestrel皮下植入物,levonorgestrel (LNG) 子宫内系统 (IUS) 和铜 (Cu) 子宫内装置 (IUD) 的安全性和有效性,超出其批准的持续时间.
- 记录与长期使用LARC相关的怀孕率和不良事件.
- 提供证据支持扩大LARC使用作为可行的避孕策略.
主要方法:
- 在MEDLINE,Embase和全球健康数据库 (2000-2023) 的系统文献搜索.
- 包括对延长使用的etonogestrel植入物,LNG-IUS和Cu-IUD的研究.
- 不包括特定的LARC类型,案例报告和非英语/法语出版物.
主要成果:
- 在长期使用乙凝植入物 (长达2年) 或TCu380A IUD (长达16年) 时,没有报告怀孕.
- 在长期使用LNG-IUS期间 (6-7年) 报告的怀孕很少.
- 对于TCu380A IUD和52mg LNG-IUS,排泄的持续风险;其他不良事件不常见.
结论:
- 长期使用LARC是安全的,并且比短效方法有效得多.
- 扩大LARC的使用对那些无法获得医疗保健的人或生活在偏远地区的人特别有益.
- LARCs提供了一个可靠和有效的长期避孕解决方案.
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