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Updated: May 27, 2025

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血清homocysteine度水平与牙脱落之间的关联:来自NHANES 2003-2006的一项横截面研究
Shiyi Luo1,2, Zefei Liu3, Xuanyan Gu1,2
1Guiyang Hospital of Stomatology, Guiyang, 550005, Guizhou, China.
Journal of bone and mineral metabolism
|February 18, 2025
概括
较高的血清homocysteine水平与40岁以上成年人的牙损失增加有关. 保持最佳的同类氨酸 (Hcy) 水平对于保持口腔健康和预防牙脱落至关重要.
科学领域:
- 口腔健康研究 口腔健康研究
- 生物标志物的分析分析.
- 公共卫生 公共卫生
背景情况:
- 血清homocysteine (Hcy) 的升高是各种健康问题的潜在危险因素.
- Hcy水平与牙脱落之间的关联需要进一步研究.
- 了解这种联系可以为预防性口腔健康策略提供信息.
研究的目的:
- 为了研究血清类固醇水平与牙损失之间的关联.
- 为了探索血清同型半氨酸对缺失牙数量的值效应.
- 分析剂量-反应关系,并确定影响这种关联的潜在共变量.
主要方法:
- 使用NHANES数据 (2003-2006) 来自4746名参与者 (≥40岁) 的横截面研究.
- 负二项回归分析,以评估血清Hcy与牙损失之间的关联.
- 不线性和值效应分析,使用平滑曲线拟合.
主要成果:
- 与最低四分位数 (Q1) 相比,较高的血清Hcy水平 (Q2-Q4) 与牙损失的可能性增加显著相关.
- 在血清Hcy和牙损失之间观察到非线性,正相关性.
- 在大约log2 ((Hcy) = 2.95 μmol/L时,确定了一个值效应.
结论:
- 血清Hcy水平每增加一个单位,牙脱落的可能性增加47%.
- 血清homocysteine是牙损失的重要预测因子,具有定义的值.
- 维持健康的同类氨酸水平对于保持口腔健康至关重要.
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