在COVID-19后的个体中,肠道微生物组合的变化和炎症标记物的增加
Tatiana Barichello1,2,3, Bruno Kluwe-Schiavon4, Laura A Borba5
1Translational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, Mcgovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Molecular neurobiology
|February 18, 2025
概括
长期COVID幸存者表现出改变的肠道细菌和增加的炎症,可能会影响神经健康. 这项研究发现,在COVID-19后的个体中,阿克尔曼西亚减少和IL-17水平提高,这表明免疫和微生物组的变化有助于持续的症状.
科学领域:
- 神经免疫学 神经免疫学
- 微生物组研究 微生物组研究
- 传染病研究 传染病研究
背景情况:
- 感染SARS-CoV-2可能会导致幸存者的长期神经复杂症.
- 免疫系统功能障碍和微生物组变化与持续的COVID-19后症状有关.
研究的目的:
- 调查肠道微生物组组成,外围炎症概况和长期COVID-19患者潜在的行为变化之间的关系.
- 为了确定特定的微生物和炎症标志物,与COVID-19后的持续性疾病相关.
主要方法:
- 横截面研究,将COVID-19后的个人与非COVID-19对照进行比较.
- 使用标准化尺度 (HAM-A,HAM-D,BRIAN,FAST) 评估精神疾病的情况.
- 血分析脂质和炎症标志物 (MPIF-1,IL-17) 和便样本以检测肠道微生物组合 (16S rRNA测序).
主要成果:
- 在COVID-19后的个人表现出高水平的骨髓原体抑制因子1 (MPIF-1),互白素 (IL) -17和甘油三.
- 肠道微生物组分析显示,群体之间的β-多样性存在显著差异,在COVID-19后的受试者中,Verrucomicrobia和Akkermansia属的丰度下降.
- 在α-多样性或行为和临床数据之间没有发现显著差异.
结论:
- 肠道微生物组合的变化,特别是Verrucomicrobia和Akkermansia的减少,以及外围炎症 (IL-17,MPIF-1) 的增加,与COVID-19后的状况有关.
- 这些免疫和微生物组失调可能导致长期COVID-19幸存者观察到的持续的神经和行为问题.
- 需要进一步的研究来探索长期COVID中准微生物组和炎症的因果关系和治疗潜力.
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