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Updated: May 27, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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河马和MAPK通路激活之间的合作驱动了对TEAD抑制的获得性抵抗

Sayantanee Paul1, Thijs J Hagenbeek1, Julien Tremblay2

  • 1Department of Discovery Oncology, Genentech Inc, South San Francisco, CA, USA.

Nature communications
|February 18, 2025
PubMed
概括

在癌症中,由于AP-1 (激活蛋白-1) 活性增加和恢复YAP (是-关联蛋白) -TEAD结合,因此出现了对TEAD抑制剂的耐药性. MAPK通路抑制剂可以在依赖Hippo通路的癌症中克服这种抵抗.

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