非狄卡里亚真菌与动物共享TORC1通路,而不是与Saccharomyces cerevisiae共享
Drishtee Barua1, Magdalena Płecha1, Anna Muszewska2
1Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, Warsaw, 02-106, Poland.
Scientific reports
|February 18, 2025
概括
菌类的目标是拉巴胺素复合体1 (TORC1) 途径.
科学领域:
- * 分子生物学 * 分子生物学
- * 进化生物学 进化生物学
- * 菌群学 * 菌群学
背景情况:
- * 拉巴胺素 (TOR) 激酶的目标是细胞生长和新陈代谢的关键调节者.
- *TOR复合体1 (TORC1) 协调细胞对酵母和哺乳动物营养可用性的反应.
- *酵母和哺乳动物之间TORC1抑制机制存在显著差异.
研究的目的:
- * 调查整个真菌王国的TORC1通路组件的进化史.
- *将真菌TORC1调节与哺乳动物和酵母模型进行比较.
- * 为了确定TORC1研究的替代真菌模型.
主要方法:
- *对TORC1通路基因进行比较基因组学和遗传学分析.
- * 在各种真菌物种中识别和表征正义学.
- * 保存和分离的监管元素的进化追踪.
主要成果:
- *非迪卡里亚真菌具有类似哺乳动物的TORC1抑制复合体 (例如,KICSTOR).
- * 哺乳动物营养传感器 (氨酸,氨酸,氨酸) 的正方体存在于真菌中.
- * 通过Rheb-TSC的哺乳动物类TORC1激活在非Dikarya中保存,但在Saccharomycotina中丢失.
结论:
- *非迪卡里亚真菌中的TORC1通路与哺乳动物的通路非常相似.
- * 糖菌菌类真菌已经简化了TORC1的调节,失去了关键的抑制成分.
- * 这项研究强调了Saccharomyces cerevisiae作为通用真菌模型的局限性.
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