来自高灵敏度C反应蛋白和心力衰竭的新型炎症标志物之间的关系:一个横截面研究
Peng Zhang1,2,3, Degang Mo1,2,3, Fanhui Lin1,2,3
1Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong, China.
高灵敏度C-反应蛋白与HDL-C比率 (HCHR) 和高灵敏度C-反应蛋白与淋巴细胞计数比率 (HCLR) 与心力衰竭 (HF) 的更高风险有关. 这些炎症标志物与美国成年人中HF患病率有显著的关联.
科学领域:
- 心血管医学 心血管医学
- 炎症生物标志物 炎症生物标志物
- 公共卫生 公共卫生
背景情况:
- 心力衰竭 (HF) 是与慢性炎症相关的重大公共卫生问题.
- 新的炎症指标,如高灵敏度C-反应蛋白与HDL-C比率 (HCHR) 和高灵敏度C-反应蛋白与淋巴细胞计数比率 (HCLR) 的新型炎症指标,可能有助于了解HF的发病性.
研究的目的:
- 调查HCHR,HCLR和美国成年人心力衰竭 (HF) 患病率之间的关联.
- 探索这种关系的性质,包括潜在的非线性关联和诊断疗效.
主要方法:
- 这是一项对来自国家健康和营养检查调查 (NHANES,2015-2018) 的8751名参与者的横截面分析.
- 采用多变量逻辑回归,平滑曲线拟合,值效应分析,子组分析和接收器操作特征 (ROC) 曲线分析.
- 用Ln转换的HCHR和HCLR来评估与高频率的关联.
主要成果:
- 较高的Ln{HCHR}和Ln{HCLR}三位数显著与高血压风险增加有关 (分别为OR=1.45和OR=1.52).
- 观察到Ln ((HCHR) 和HF之间存在非线性关系,转折点为-2.71.1.
- 与Ln(HCHR) (AUC:0.620) 相比,Ln(HCLR) 的HF诊断疗效更高 (AUC:0.638).
结论:
- 两种Ln(HCHR) 和Ln(HCLR) 都与美国成年人心力衰竭的患病率有关.
- 这些炎症比率可以作为HF风险分层和诊断的潜在指标.
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