怀孕前使用子宫内器械与随后早产的风险降低有关:一项基于大量人口的队列研究
Xing Chen1, Tao Wang2,3, Yan Zhang1
1NHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, School of Public Health, Fudan University, Shanghai, China.
BMC public health
|February 18, 2025
概括
在怀孕前使用宫内器械 (IUD) 与早产风险降低有关. 这种保护作用在居住在社会经济发展正常的地区的妇女中更为明显.
科学领域:
- 生殖健康 生殖健康
- 孕产妇健康 孕产妇健康
- 公共卫生 公共卫生
背景情况:
- 在怀孕前使用宫内器械 (IUD) 和随后的早产 (PTB) 之间的联系需要进一步调查.
- 现有的研究还没有明确确定妊娠前IUD使用对PTB发生率的影响.
研究的目的:
- 检查在怀孕前使用宫内节育器和PTB发生之间的关系.
- 探索妊娠前宫内节育器使用与社会经济因素之间的潜在相互作用,特别是县级贫困,与PTB风险相关.
主要方法:
- 在云南 (2013-2019) 的全国免费预孕健康检查项目 (NFPHEP) 中,对240,437名妇女进行了一项大型队列研究.
- 参与者被分为非方法使用者,宫内避孕器使用者和其他避孕方法使用者.
- 采用多变量波桑回归来评估妊娠前IUD使用与PTB之间的关联,并进一步分析与县剥夺的相互作用.
主要成果:
- 怀孕前使用避孕套与PTB风险显著降低有关 (调整后相对风险[aRR] 0.84).
- 使用IUD的女性的PTB率较低 (4.86%),与非方法使用者 (5.42%) 和其他方法使用者 (5.33%) 相比.
- 在怀孕前IUD使用和县发展水平之间发现了显著的相互作用,通常发达地区的IUD使用者显示PTB风险降低了30%.
结论:
- 在怀孕前使用宫内节育器显然与随后早产的风险降低有关.
- 在正常社会经济发展的地区,与最不发达地区相比,妊娠前IUD使用对PTB的保护性关联更为显著.
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