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下肢肌肉强度与晚期或复发性肺癌患者的预后有关:一项回顾性观察性研究

Takuya Fukushima¹, Utae Katsushima², Naoya Ogushi³

¹Faculty of Rehabilitation, Kansai Medical University, Hirakata, Osaka, Japan. fukustak@makino.kmu.ac.jp.

|February 18, 2025

概括

在肺癌患者中,手握和下肢力量的减少,而不是骨肌肉指数,预测死亡率. 身体不活动与肌肉衰弱有关,强调了需要进行运动干预的必要性.

科学领域:

在瘤学瘤学.
老年病的医生老年病的医生
康复医学康复医学康复医学

背景情况:

标志着肌肉损失和软弱的萨科佩尼亚在晚期肺癌中很普遍.
包括骨肌肉指数 (SMI),手握强度和下肢肌肉强度在内的各种类型的麻症指数可能会影响预后.
确定主要的肉症指标和相关因素对于制定有针对性的干预措施至关重要.

研究的目的:

调查多重萨科佩尼亚指数与晚期或复发性肺癌患者全因死亡率之间的关联.
确定影响萨科佩尼亚指数的因素,这些因素与预后有很强的相关性.
为肺癌患者制定有针对性的干预策略提供信息.

主要方法:

对接受化疗的肺癌门诊患者进行了回顾性观察性研究.
评估肉类症指数:SMI,手握强度,五次重复的坐立测试 (5STS) 和SARC-F.
预测关联使用日志等级测试和Cox比例危险模型进行评估;通过C指数量化预测能力;通过多变量后勤回归确定影响因素.

主要成果:

手握强度低,下肢肌肉强度受损 (5STS ≥12秒) 和结合性肉症与死亡率显著相关 (P <0.05).
骨肌肉指数 (SMI) 和SARC-F显示没有与生存的显著关联 (P>0.05).
身体活动 (IPAQ-SF) 是一个独立的因素,与下肢肌肉强度和综合性肉相关 (P < 0.001).

结论:

在肺癌患者中,手握和下肢肌肉力量是比SMI更强的预后指标.
身体不活动与较低的下肢肌肉强度显著相关.
建议对下肢力量和身体活动进行临床评估,加上运动干预措施.

关键词:

下肢肌肉的强度和力量.肺癌是一种肺癌.预测预后预测预测萨尔科佩尼亚是什么意思萨尔科佩尼亚

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