在影响部的牙病原性感染中,用全身性抗菌药物治疗的最佳治疗时间:系统性审查
Eduardo Dias Ribeiro1, Ilan Hudson Gomes de Santana2, Mayara Rebeca Martins Viana3
1Department of Clinical and Social Dentistry (DCOS), Health Sciences Center at the Federal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil.
BMC oral health
|February 19, 2025
概括
当与手术相结合时,较短的抗生素持续时间 (3-5天) 对于下牙感染是有效的. 根据患者的病情和局部耐药性量身定制治疗对于获得最佳结果和预防耐药性至关重要.
科学领域:
- 口腔和牙面部外科手术
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 下巴的牙感染需要有效的抗菌治疗.
- 目前的临床指南缺乏针对最佳抗菌药物治疗持续时间的具体建议.
- 确定理想的持续时间对于患者的治疗结果和抗微生物药物管理至关重要.
研究的目的:
- 系统地审查和分析关于下口口腔病原性感染抗微生物药物治疗的有效和安全持续时间的文献.
- 解决这些感染中抗微生物治疗持续时间的基于证据的指导方针中的差距.
主要方法:
- 在PROSPERO (CRD42024551258) 中注册的系统审查.
- 在多个数据库 (PubMed,科学网,Scopus等) 中进行全面搜索. 在2024年6月16日之前.
- 优先考虑随机临床试验 (RCT),评估不同抗菌药物治疗持续时间.
主要成果:
- 最初确定了3,446篇文章;最终分析包括了8项研究.
- 较短的抗生素疗程 (3-5天) 在与外科手术一起使用时显示出有效性.
- 这种方法有助于最大限度地减少并发症,并打击细菌耐药性.
结论:
- 选择和持续时间应根据临床状态,感染严重程度和局部耐药性模式进行个性化治疗.
- 氨基素通常是有效的,但可能需要替代品,如西普罗夫洛克萨或美特罗尼达.
- 需要进一步的RCT来完善基于证据的指导方针,以获得最佳治疗持续时间.
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