与周围神经病变,膜性神经病变和间歇性肺部疾病相关的免疫球蛋白G4相关疾病:一个病例报告
Tianhang Yu1, Qiao Ye1, Fang Luo1
1Department of Rheumatology, The Second Affiliate Hospital of Jiaxing University, Jiaxing, China.
International journal of rheumatic diseases
|February 19, 2025
概括
本案例研究强调了一种罕见的免疫球蛋白G4相关疾病 (IgG4-RD) 呈现,其主要症状是外围神经病变. 用环胺和甲基prednisolone的治疗改善了这个老年患者的多器官参与.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 腎臟病學 (nephrology) 是一種醫學.
- 肺部病理学 肺部病理学
背景情况:
- 免疫球蛋白G4相关性疾病 (IgG4-RD) 是一种由纤维化特征的多系统性炎症性疾病.
- 症状的外周神经干扰是IgG4-RD的一个不常见的表现.
研究的目的:
- 报告一种异常的IgG4-RD病例,主要表现为外围神经病变.
- 描述多系统IgG4-RD患者的诊断过程和治疗结果.
主要方法:
- 一个77岁的中国男性患有外围神经病变,膜性神经病变和间歇性肺部疾病的病例报告.
- 诊断工作包括血液测试 (IgG4水平),胸部CT,电肌图和脏活检.
- 治疗涉及环胺和高剂量的甲基prednisolone.
主要成果:
- 患者呈现出高的IgG4水平和IgG4/IgG比率.
- 图像检测显示了间歇性肺炎和中间腺淋巴病.
- 电肌图证实了下肢的神经和轴突损伤.
- 脏活检显示膜性脏病与IgG4阳性血细胞.
- 治疗导致神经病变,蛋白尿和肺部疾病严重程度的改善.
结论:
- 这一案例强调了IgG4-RD的不同临床表现,强调了外围神经病变作为潜在的主要特征.
- 早期诊断和适当的免疫抑制疗法对于管理多系统IgG4-RD至关重要,即使是在不寻常的呈现.
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