评估双参数MRI用于诊断肌肉侵入性膀癌与变异性尿组织学:一个多中心研究
Peikun Liu1,2, Lingkai Cai1,3, Hongliang Que4
1Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
概括
使用多参数MRI (mp-MRI) 的膀成像报告和数据系统 (VI-RADS) 有效地诊断肌肉侵入性膀癌 (MIBC) 在变异性组织学泌尿瘤 (VUC) 中. 双参数MRI (bp-MRI),特别是T2加权成像 (T2WI),显示了与mp-MRI对VUC的诊断性能相似的诊断性能.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 使用多参数MRI (mp-MRI) 的膀成像报告和数据系统 (VI-RADS) 是有效的诊断纯尿路细胞癌 (UC) 肌肉侵入性膀癌 (MIBC).
- 对于具有变异组织学 (VUC) 的UC,VI-RADS与mp-MRI和双参数MRI (bp-MRI) 的诊断性能尚未得到充分确立.
研究的目的:
- 评估VI-RADS使用mp-MRI和bp-MRI在VUC患者中诊断MIBC的实用性.
- 为了比较bp-MRI内不同MRI序列的诊断准确度,用于VUC.
主要方法:
- 对接受mp-MRI的86名VUC患者的回顾性分析.
- 在mp-MRI和两个bp-MRI标准 (bp-DWI和bp-T2WI) 上应用了VI-RADS评分.
- 使用卡帕分析评估读者间一致性;通过ROC曲线和AUC比较评估诊断性能.
主要成果:
- 在所有方法中观察到高的读者间一致性 (Kappa > 0.80).
- mp-MRI的AUC值为0.934;bp-T2WI的AUC值为0.932,与mp-MRI (p=0.682) 的AUC值相当.
- 与bp-T2WI (p=0.007) 相比,bp-DWI显示较低的AUC (0.885);mp-MRI和bp-T2WI都显示出高灵敏度和特异性.
结论:
- 基于mp-MRI的VI-RADS是诊断VUC中的MIBC的一个有价值的工具.
- 在VUC中,bp-T2WI的诊断性能与MP-MRI对MIBC的诊断性能相当,这表明它作为替代方案的潜力.
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