结肠输送和受控释放的黄素被封装在植物性细胞外囊泡中,装入水凝珠中
Hang Liu1, Yikun Liu1, Shengfeng Peng2
1State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, Jiangxi, PR China.
Food research international (Ottawa, Ont.)
|February 19, 2025
概括
香细胞外囊泡 (EVs) 有效封装黄素,提高其生物可访问性. 将这些含有黄素的EV装入水凝珠中,进一步提高了稳定性和受控释放,提高了治疗潜力.
科学领域:
- 生物材料科学 生物材料科学
- 营养药物输送系统 营养药物输送系统
- 基于植物的纳米技术
背景情况:
- 疏水性营养品,如黄素,往往患有不良溶解性和低生物可用性.
- 来自自然来源的细胞外囊泡 (EVs) 提供了作为生物相容载体的潜力,用于增强输送.
- 香汁为植物性电动汽车提供了一个新的来源,具有适合营养药封装的固有特性.
研究的目的:
- 研究香衍生的细胞外囊泡 (EVs) 作为疏水性营养品的新型载体,特别是黄素.
- 通过在香EV中进行封装来提高黄素的生物可访问性和稳定性.
- 开发一种含有黄素的香EVs的水凝珠传递系统,以控制释放和提高治疗疗效.
主要方法:
- 黄素在香汁衍生的EVs中的无形状态中的溶解.
- 载有黄素的电动汽车 (CEV) 的表征和与纯黄素晶体的比较.
- 制造水凝珠,使用藻酸盐和香点封装CEVs.
- 评估水凝珠的特性 (球形,硬度,保持水的容量) 和膨胀行为.
- 在各种条件下 (加热,储存,pH) 评估黄素释放动力学和稳定性.
主要成果:
- 香EVs成功封装了黄素,与晶体黄素相比,显著增加了其生物可访问性.
- 含有CEV的水凝珠表现出改善的物理化学特性和受控的黄素释放.
- 水凝系统证明了黄素对热量,暴露和储存的增强稳定性.
- 在水凝珠中的封装减缓了黄素的释放,显示出性结肠炎治疗的潜力.
结论:
- 香衍生的EV是有效的天然载体,可以携带水性营养品,如黄素.
- CEV的凝珠封装提供了一个强大的系统,用于控制释放和增强稳定性.
- 这种基于植物的输送系统有望改善营养药的功能性能和治疗应用.
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