沙叶酸培通过肠肝轴调节血糖:肠道微生物/SCFA/FoxO1信号通路
Qing Guo1, Xiaoxue Wang1, Jingxuan Ke2
1College of Food Science, Sichuan Agricultural University, Ya'an, Sichuan 625014, China.
Food research international (Ottawa, Ont.)
|February 19, 2025
概括
酸 (CP) 通过改善肠道健康,增加有益细菌,并激活GLP-1和AMPK等关键信号通路,有效降低2型糖尿病的血糖.
科学领域:
- 代谢研究的研究.
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 酸果及其化合物显示出抗糖尿病作用.
- 有限的研究存在于酸甲 (CP) 在调节2型糖尿病 (T2DM) 血糖的具体机制.
研究的目的:
- 为了研究酸盐培 (CP) 调节血糖水平的潜在机制.
- 在T2DM小鼠模型中探索CP对胰岛素抵抗,肠道微生物群和肠道屏障功能的影响.
主要方法:
- 对db/db小鼠进行了为期8周的CP给药.
- 分析葡萄糖类 (GLP-1) 分泌,肝脏葡萄糖原和恒温模式评估-胰岛素抵抗 (HOMA-IR) 的分析.
- 西部涂抹以评估与PI3K/AKT/FoxO1和GPR43/AMPK/FoxO1通路相关的蛋白质表达,肠道微生物群分析和肠道屏障评估.
主要成果:
- 脑膜炎治疗提高了GLP-1分泌量,增加了肝脏的葡萄糖原,并减少了HOMA-IR.
- CP调节了葡萄糖代谢中的关键蛋白质 (PI3K,P-AKT,FoxO1,G6Pase,PEPCK) 并激活了肝脏GPR43/P-AMPK信号传导.
- CP改善了肠道微生物群的组成,增加了有益细菌,降低了Firmicutes/Bacteroidetes比率,增强了杯状细胞,并提高了肠道屏障蛋白 (Claudin-1, Mucin-2).
结论:
- 通过通过肠道微生物群/SCFA/GLP-1,PI3K/AKT/FoxO1和GPR43/AMPK/FoxO1信号通路激活肠肝轴,CP调节血糖.
- 这些发现支持CP的发展,作为一种功能性食品成分,用于管理2型糖尿病.
更多相关视频
相关概念视频
01:26Glucose Absorption Into the Small Intestine
31.2K
Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
31.2K
01:30Regulation of Food Intake
179
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
179
01:01Feedback Loops
55.6K
In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
55.6K
01:58Cell Specific Gene Expression
13.4K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.4K
01:40Hormonal Regulation
43.1K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
43.1K
01:02Glucose Homeostasis: Regulation of Blood Glucose
1.4K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
1.4K