在早产新生儿的腹腔营养中限制:一个试点随机对照试验
Jason B Sauberan1, Anup C Katheria1
1Neonatal Research Institute, Sharp Mary Birch Hospital for Women and Newborns, San Diego, California, USA.
概括
在早产婴儿的腹腔营养中省略补充 (Mn) 是可行的和安全的. 这种方法没有影响血液中Mn水平或婴儿在生命的前八周的成长.
科学领域:
- 新生儿营养新生儿营养
- 微量元素的新陈代谢
- 儿科重症监护室的重症监护室
背景情况:
- 亲肠道营养 (PN) 中的 (Mn) 污染是早产新生儿的担忧.
- 较高的Mn暴露可能会导致这种脆弱人群的不良健康结果.
研究的目的:
- 评估极早和极早新生儿在PN中扣留补充Mn的可行性和安全性.
- 为了将结果与标准的Mn补充方案进行比较.
主要方法:
- 随机对照试验涉及新生儿<32周妊娠年龄.
- 与没有添加的PN进行比较 (5微克/公斤/天).
- 监测全血Mn水平,生长参数和营养摄入量.
主要成果:
- 在基线,2周或8周,两组之间全血Mn水平没有显著差异.
- 在没有添加Mn和标准Mn组中观察到类似的生长和营养结果.
- 在常规护理中,无添加Mn PN的可行实施.
结论:
- 在PN中保留补充Mn对于早产婴儿来说是安全的和可行的.
- 没有添加的Mn PN不会对生命最初8周的血中Mn水平或生长产生负面影响.
- 这一策略为新生儿营养支持提供了潜在的修改.
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