相关实验视频

Updated: May 27, 2025

Author Spotlight: Studying Drug Impacts on Brain Signals Using Dual LFP Recording Protocol in Mice
04:44

Author Spotlight: Studying Drug Impacts on Brain Signals Using Dual LFP Recording Protocol in Mice

Published on: February 16, 2024

1.4K

持续多巴胺D2受体阻塞和第一次精神分裂症的长期结果

Jari Tiihonen1, Antti Tanskanen1, Marco Solmi1

  • 1Department of Forensic Psychiatry, University of Eastern Finland, and Niuvanniemi Hospital, Kuopio, Finland (Tiihonen, Tanskanen, Taipale); Department of Clinical Neuroscience, Karolinska Institutet, Stockholm (Tiihonen, Tanskanen, Taipale); Center for Psychiatry Research, Stockholm City Council, Stockholm (Tiihonen, Tanskanen, Taipale); SCIENCES Lab and Department of Psychiatry, University of Ottawa, Ottawa (Solmi); On Track: The Champlain First Episode Psychosis Program, and Regional Centre for the Treatment of Eating Disorders, Department of Mental Health, Ottawa Hospital, Ottawa (Solmi); Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa (Solmi); Department of Child and Adolescent Psychiatry, Charité-Universitätsmedizin Berlin, Berlin (Solmi, Correll); Department of Psychiatry, Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY (Rubio, Correll, Kane); Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY (Rubio, Correll, Kane); Institute for Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, NY (Rubio, Kane); German Center for Mental Health, partner site Berlin (Correll); School of Pharmacy, University of Eastern Finland, Kuopio (Taipale).

The American journal of psychiatry
|February 19, 2025
PubMed
概括

尽管持续阻断多巴胺D2受体,但大约40%-50%的第一发精神分裂症患者复发. 长期的D2阻塞不会增加突破性精神病的风险,这表明疾病复发中的非多巴胺基因因素.

关键词:
抗精神病药物 抗精神病药物多巴胺是一种多巴胺.第一集的第一集.复发复发的情况精神分裂症谱系和其他精神病障碍

更多相关视频

Development of a Virtual Reality Assessment of Everyday Living Skills10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

18.3K
Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation09:39

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Published on: June 7, 2016

10.4K

相关概念视频

Antipsychotic Drugs: Typical and Atypical Agents01:21

Antipsychotic Drugs: Typical and Atypical Agents

Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
149
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
171
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
102
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
35
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
382
Antipsychotic Drugs: Therapeutic Uses and Side Effects01:21

Antipsychotic Drugs: Therapeutic Uses and Side Effects

Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
118