复发性口腔与口腔生物多样性之间的关联:系统性审查和元分析
Lin Zhao1, Hongyu Xie1, Lunwei Kang1
1West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Journal of evidence-based medicine
|February 19, 2025
概括
复发性口腔 (RAU) 与口腔微生物失衡有关. 这项研究发现RAU患者的微生物多样性较低,这表明失生症有助于的发展.
科学领域:
- 微生物学 微生物学
- 口腔健康 口腔健康
- 免疫学 免疫学 免疫学
背景情况:
- 复发性口腔 (RAU) 是一种常见的,痛苦的口腔病变.
- RAU的病因是多因素的,怀疑微生物参与.
- 了解口腔微生物组的作用是RAU病变发生的关键.
研究的目的:
- 调查复发性胃口 (RAU) 和口腔微生物群失生症之间的关联.
- 量化评估RAU患者和健康对照之间的口腔微生物多样性和丰富性的差异.
主要方法:
- 在主要数据库 (PubMed,科学网,Embase等) 进行系统的文献搜索. 在2024年9月之前.
- 使用纽卡斯尔-太华尺度对所包含研究的质量评估.
- 随机效应的元分析,以合成关于微生物多样性 (alpha和beta) 和丰度的数据.
主要成果:
- 包括10项研究 (343名患者,348名对照);7项进行了元分析.
- 与对照组相比,RAU患者在唾液中显示出明显较低的α多样性 (Chao 1指数) (MD = -41.22,p < 0.01).
- 患有的口腔部位的Chao 1指数高于患者的健康口腔粘膜部位 (MD = 27.48,p = 0.03).
结论:
- 在RAU患者和对照人群之间微生物多样性的显著差异 (Chao 1指数) 支持dysbiosis.
- 贝塔多样性和特定种群丰度的变化进一步表明微生物失生症在RAU发展中的作用.
- 这些发现凸显了口腔微生物组作为复发性口腔病原发生的潜在因素.
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