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系统性炎症反应指数与2005年至2008年的玻璃眼病发病率之间的关联

Xiang Li¹, Yi Qing Sun², Xiao Dan Zhong³

¹Eye Institute and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, China.

Frontiers in medicine

|February 19, 2025

概括

系统性炎症反应指数 (SIRI) 水平的升高与更高的青光眼的患病率有关. 这一发现表明系统性炎症可能在青光眼发育中起作用,可能有助于早期检测.

科学领域:

眼科和全身疾病研究.
调查炎症标志物和眼部疾病之间的联系.

背景情况:

玻璃眼是全球不可逆转的失明的主要原因.
系统性炎症越来越被认为是各种慢性疾病的促成因素.
系统性炎症反应指数 (SIRI) 是一种复合的炎症标志物.

研究的目的:

检查系统性炎症反应指数 (SIRI) 和青光眼患病率之间的关联.
探索SIRI作为青光眼风险生物标志物的潜力.

主要方法:

从2005-2008年国家健康和营养检查调查 (NHANES) 中对4,514名参与者的横截面分析.
从血液样本计算SIRI和其他炎症指数 (SII,PLR,NLR).
后勤回归模型用于评估炎症指数和青光眼之间的关系,调整共变量.

主要成果:

在升高的LOG2SIRI水平和青光眼患病率 (OR1.24,95%CI1.07-1.44) 之间观察到显著的积极关联.
记录2的最高四分位数SIRI (Q4) 显示了与青光眼发生的显著关联 (OR 1.62,95% CI 1.12-2.34).
接收机操作员特征曲线 (AUC) 下的面积支持模型3中SIRI的预测值 (AUC=0.674).

结论:

较高的SIRI水平与较高的青光眼患病率有显著的关联.
根据SIRI的指示,系统性炎症可能会导致青光眼病原性.
SIRI有可能作为一种有价值的生物标志物,用于早期的青光眼检测和风险分层.

关键词:

尼汉斯 (NHANES) 是一个名人.生物标志物生物标志物玻璃眼 glaucoma 玻璃眼玻璃眼玻璃眼玻璃眼系统性炎症系统性炎症系统性炎症反应指数

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