脂质积累产品与炎症参数和死亡率的关联:来自大型人口研究的证据
Yi Chi1, Yiqing Zhang1, Huang Lin1
1Department of Integrative Medicine (Geriatrics), The People's Hospital Medical Group of Xiangzhou, Zhuhai, China.
Frontiers in epidemiology
|February 19, 2025
概括
腹部体积指数 (AVI) 与高血压老年人死亡率的增加有关. 炎症标志物部分解释了这种关联,突出了它们在心血管健康中的作用.
科学领域:
- 老年学是一门学科.
- 心血管疾病 心血管疾病
- 代谢综合征是代谢综合征的一种.
背景情况:
- 肥胖和脂质代谢与慢性炎症和心血管疾病风险有关.
- 腹部体积指数 (AVI) 是一种新的脂质积累标志物.
- 了解AVI,炎症和死亡率之间的关系对于公共卫生至关重要.
研究的目的:
- 调查腹部体积指数 (AVI) 与高血压老年人死亡率之间的关联.
- 探索炎症参数作为AVI和死亡率之间的关系中介者的作用.
主要方法:
- 分析了来自NHANES的2,109名高血压老年人 (年龄>60岁) 的队列.
- 全因和心血管死亡率是主要终点,与国家死亡指数相关.
- 考克斯回归,受限立方线和调解分析被用来评估炎症标志物 (SIRI,MHR,NLR) 的关联和调解效应.
主要成果:
- 平均69个月的随访时间显示,有1260人死亡 (337人死于心血管疾病).
- 多变量分析显示,AVI与所有原因 (HR=1.09) 和心血管死亡率 (HR=1.07) 有积极关联.
- 炎症标志物 (SIRI,MHR,NLR) 分别占AVI与所有原因死亡率相关性的27.15%,35.15%和16.55%.
结论:
- 腹部体积指数 (AVI) 是高血压老年人全因死亡率的重要预测指标.
- 炎症参数部分调解了AVI和死亡率之间的关联,强调了它们在这种关系中的作用.
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