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高热和准热冲击蛋白:神经退行性疾病和长期COVID的创新方法

David M Smadja^1,2, M Marc Abreu^3,4

¹Paris Cité University, INSERM, Paris Cardiovascular Research Centre, Team Endotheliopathy and Hemostasis Disorders, Paris, France.

Frontiers in neuroscience

|February 19, 2025

概括

全身高温症 (WBH) 是通过增强细胞修复和减少神经炎症来治疗神经退行性疾病和长期COVID的前景. 需要进一步的研究,以建立标准化的协议和个性化治疗,以获得最佳的疗效.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
治疗方法治疗方法

背景情况:

神经退行性疾病 (ND) 和长期COVID由于神经元损伤,蛋白质错折和神经炎症而带来了重大的全球健康挑战.
目前的药理疗法往往难以解决这些疾病背后的复杂病理生理机制.

研究的目的:

探索全身高温症 (WBH) 作为ND和长期COVID的创新治疗方法的潜力.
研究WBH如何调节关键的病理生理过程,包括线粒体功能,热冲击蛋白 (HSP) 诱导和神经炎症.

主要方法:

现有文献和关于WBH对发烧范围温度的影响的初步发现的综述.
分析WBH对蛋白质折叠,聚合,细胞保护,免疫调节和生理途径恢复的影响.
考虑WBH应用的挑战和未来研究方向.

主要成果:

WBH增强线粒体功能,诱导保护性热冲击蛋白 (HSP如HSP70和HSP90),并调节神经炎症.
高质量蛋白质在防止蛋白质聚合中发挥着至关重要的作用,这是阿尔茨海默氏症和帕金森病等ND的标志.
初步证据表明,WBH可以通过解决神经炎症和血清激素失调来缓解长期COVID中的神经症状.

结论:

通过准基本疾病机制,WBH为ND和长期COVID提供了一个有前途的治疗途径.
由于高热对炎症反应的双重影响,仔细,剂量控制的应用和患者监测是必不可少的.
需要进一步的有针对性的临床试验,生物标志物识别和个性化策略来优化WBH的疗效和可访问性.

关键词:

长时间的COVID.热冲击是一种热冲击.过热症过热症是什么?神经退行性疾病的神经退行性疾病血清胺 (serotonin) 是一种神经元.

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