在COVID-19和成人COVID后并发症期间的甲状腺功能:系统性审查
Anisha Panesar1, Palma Gharanei1, Natasha Khovanova2
1Warwick Medical School, University of Warwick, Coventry, United Kingdom.
Frontiers in endocrinology
|February 19, 2025
概括
COVID-19 (冠状病毒疾病2019) 可以通过直接的病毒效应或免疫反应引起甲状腺功能障碍. 本综述检查了急性感染和长期COVID期间的甲状腺问题,影响内分泌健康.
科学领域:
- 内分泌学 在内分泌学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 由SARS-CoV-2引起的COVID-19流行病影响了包括内分泌系统在内的多个器官系统.
- 新出现的证据将COVID-19与甲状腺功能障碍联系起来,影响急性疾病和长期的COVID后续.
- 通过各种机制,SARS-CoV-2感染可以导致甲状腺炎和改变甲状腺激素水平.
研究的目的:
- 系统地审查有关成人COVID-19相关甲状腺功能障碍的最新文献.
- 在急性COVID-19期间分析甲状腺功能障碍的预后后果.
- 研究甲状腺功能障碍对长期COVID患者的影响.
主要方法:
- 在PubMed和EMBASE数据库中进行了全面的文献搜索.
- 系统性审查遵循了系统性审查和元分析 (PRISMA) 的首选报告项目指南.
- 研究质量是使用关键评估技能计划 (CASP) 清单来评估的.
主要成果:
- 总共有53项研究符合审查的纳入标准.
- COVID-19可以通过甲状腺细胞的直接病毒感染,细胞因子风暴或药物的副作用来诱导甲状腺功能障碍.
- 在长期的COVID中,甲状腺功能障碍可能会持续,可能是由于慢性炎症或下丘脑-垂体-甲状腺轴的干扰.
结论:
- 在急性疾病期间,SARS-CoV-2感染显著影响甲状腺功能,并可能导致长期COVID的持续内分泌问题.
- 了解这些与甲状腺有关的影响对于管理整个COVID-19频谱的患者至关重要.
- 需要进一步的研究才能充分阐明COVID-19后甲状腺功能障碍的机制和长期影响.
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