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叶酸功能化CS/rGO/NiO纳米复合材料作为一种具有抗微生物,目标特定和刺激反应能力的多功能药物载体

Sreekanth Reddy Obireddy¹, Arumugam Ayyakannu², Gopinath Kasi³

¹Department of Urology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Zhejiang, 310014, People's Republic of China.

International journal of nanomedicine

|February 19, 2025

概括

表面修改的基托桑纳米复合物与减少的氧化石墨烯/氧化提供有针对性的,对pH响应的药物输送,具有抗微生物和抗癌特性. 这些先进的材料显示出对有效的治疗应用的希望.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

酸盐 (CS) 是一种生物相容的聚合物,具有响应pH的特性.
减少的石墨烯氧化物 (rGO) 为药物加载提供了很大的表面积.
氧化 (NiO) 纳米粒子具有产生反应性氧物种 (ROS) 的能力.

研究的目的:

用于合成表面修饰的基托,涂上减少的石墨烯氧化物/氧化物 (CS/rGO/NiO) 纳米复合材料.
开发一种具有抗微生物,点特异性和刺激响应能力的多功能药物载体.
评估这些纳米复合材料在药物输送应用中的潜力.

主要方法:

CS/rGO/NiO纳米复合材料的溶热合成.
甲交叉连接以增强纳米复合材料的稳定性.
评估结构性,磁性,抗菌性,药物释放性和毒性特性.

主要成果:

合成的纳米复合材料表现出良好的生物相容性和优良的磁性.
在pH值5.0 (~98.6%) 与pH值7.4 (~9.6%) 相比,观察到高水平的多克索鲁比 (DOX) 释放.
显著抑制了A549和MCF7细胞生长,对斑马鱼胚胎存活的影响很小.

结论:

CS/rGO/NiO纳米复合材料具有多功能性,针对特定目标和pH响应的特性.
这些特性表明它们作为先进药物输送系统的有前途平台的潜力.

关键词:

生物聚合物生物聚合物药物输送是药物输送的过程.叶酸受体的受体是叶酸的受体纳米颗粒是一种纳米粒子.氧化的氧化是什么

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