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精神分裂症认知简要评估中的最小临床重要差异-日本版本复合得分:单中心初步研究
Ryo Oya1, Masaki Fujiwara2, Yuto Yamada2
1Department of Rehabilitation, Matsue Red Cross Hospital, Matsue 690-0886, Japan.
Yonago acta medica
|February 19, 2025
概括
这项研究确定了精神分裂症-日本版本 (BACS-J) 综合评分认知简要评估的初步最小临床重要差异 (MCID). 在接受认知康复的精神分裂症患者中,BACS-J评分增加约为0.7被认为是临床上有意义的.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 认知功能障碍显著影响精神分裂症患者的社会功能.
- 认知康复是改善认知缺陷的一个有前途的干预措施.
- 精神分裂症认知简要评估-日本版 (BACS-J) 是认知康复有效性的关键结果指标.
研究的目的:
- 为了计算BACS-J复合分数的初步最小临床重要差异 (MCID).
- 评估用于精神分裂症认知康复研究的回顾性数据收集的可行性.
- 建立精神分裂症治疗中有意义的认知改善的基准.
主要方法:
- 从精神分裂症患者接受认知康复的医疗记录的回顾性分析.
- 收集干预前和后的BACS-J分数.
- 使用基于分布的方法 (标准测量误差) 来估计MCID.
- 评估的临床总体印象改善 (CGI-I) 用于基于的MCID计算 (受样本大小限制).
主要成果:
- 对28名患者的数据进行了BACS-J评分分析.
- 基于分布的方法为BACS-J复合得分提供了0.735的初步MCID.
- 由于样本大小不足,无法应用基于的方法 (11名CGI-I患者,3人改善最小).
结论:
- 对BACS-J和CGI-I数据的回顾性收集和分析对于精神分裂症研究是可行的.
- BACS-J复合分数增加约0.7表示临床上有意义的改善.
- 建议在未来进行大规模研究,以使用分布和基方法来完善MCID.
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