在急性缺血性中风中,血红蛋白糖化指数和内血管血栓切除术后的不良结果之间的关联
Yan Yang1, Mei Liu1, Shungui Huang1
1Department of Neurology, The Sixth People's Hospital of Chengdu, Chengdu, China.
Frontiers in aging neuroscience
|February 19, 2025
概括
低血红蛋白糖化指数 (HGI) 与急性缺血性中风 (AIS) 患者经历内血管血栓切除术 (EVT) 的不良结果有关. 这种U形关系突出显示了HGI.
科学领域:
- 神经学 神经学
- 心血管医学 心血管医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 在急性缺血性中风 (AIS) 患者中,血红蛋白糖化指数 (HGI) 的预后意义在接受内血管血栓切除 (EVT) 治疗的患者中尚未得到充分确立.
- HGI反映了短期的血糖控制,可能会影响中风的结果.
研究的目的:
- 调查HGI与EVT治疗的AIS患者不良结果的风险之间的关联.
- 探索HGI水平和EVT后的临床结果之间的关系.
主要方法:
- 对用EVT治疗的大血管封闭症AIS患者的回顾性分析.
- 糟糕的结果被定义为修改后的兰金级评分>2在90天内.
- 用于分析HGI和结果关联的多变量逻辑回归和受限立方线曲线.
主要成果:
- 在HGI和糟糕的结果之间观察到U形关系 (P为非线性<0.001).
- 低HGI (三位数1) 与较低结果 (OR,3.84;95% CI,2.08-7.22) 和早期神经系统恶化 (OR,3.11;95% CI,1.55-6.44) 的风险增加显著相关.
- 纳入HGI提高了模型预测糟糕结果的辨别能力.
结论:
- 在HGI和EVT后AIS患者的不良结果之间存在U形关联.
- 低HGI水平与不良结果有显著的联系,这表明它在这个患者群体中的预后价值.
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