梅丽莎官提取物对肥胖和焦虑的作用
Jin Gyeom Kim1, Jiye Park1, Sooyeon Baek1
1Department of Food and Nutrition, Chungnam National University, Daejeon 34134, Korea.
Clinical nutrition research
|February 19, 2025
概括
香提取物在对抗雌性小鼠肥胖和焦虑方面表现有前途. 水和乙醇提取物都减少了体重增加和脂肪组织,其中一种提取物也减少了类似焦虑的行为.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
背景情况:
- 肥胖和焦虑是全球普遍存在的健康问题,特别影响女性.
- 荷尔蒙波动和社会压力可能会使女性的这些情况恶化.
- 寻求自然疗法来应对并发的代谢和心理健康挑战.
研究的目的:
- 研究香 (Melissa officinalis) 提取物对抗肥胖和抗焦虑的作用.
- 为了比较蒸水 (LBD) 和80%乙醇 (LBE) 提取物的疗效.
- 探索高脂肪饮食的雌性小鼠的潜在分子机制.
主要方法:
- 雌性C57BL/6小鼠 (n=16) 接受高脂肪饮食6周.
- 小鼠接受了口服取物 (LBD或LBE,200毫克/公斤/天) 或是对照.
- 评估了体重,脂肪组织 (mWAT,pWAT),基因表达 (FAS,PPARγ) 和类似焦虑的行为 (升高加迷宫).
主要成果:
- 与对照组相比,LBD和LBE都显著减少了体重增加 (27.74%和29.71%对比51.88%,p <0.05).
- 提取物减少了中腔白脂肪组织 (mWAT);LBD还减少了参数WAT (pWAT) 和mWAT中的关键基因表达 (FAS,PPARγ).
- LBD组表现出显著减少的焦虑类行为,增加了时间和距离在升高加迷宫的开放臂膀 (p <0.05).
结论:
- 香提取物在雌性小鼠中表现出对肥胖和类似焦虑行为的双重有效性.
- 提取溶剂影响特定的抗肥胖机制和减轻焦虑的影响.
- 露显示出作为一种功能性食品成分的潜力,用于管理同时存在的肥胖和焦虑,特别是在女性中.
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