AOP-networkFinder-一个多功能工具用于从AOP-Wiki重建和可视化不良结果路径网络
Nurettin Yarar1,2, Marvin Martens3, Torbjørn Rognes1,4
1Department of Informatics, University of Oslo, Oslo 0373, Norway.
Bioinformatics advances
|February 19, 2025
概括
AOP-networkFinder是一个新的工具,可以帮助研究人员可视化不良结果路径网络. 它通过关键事件连接路径,帮助毒理学研究和数据共享.
科学领域:
- 计算毒理学计算毒理学
- 生物信息学是一种生物信息学.
- 网络科学 网络科学
背景情况:
- 负面结果途径 (AOP) 维基是AOPs的关键知识库.
- 有效地重建AOP网络需要专业领域专家的专门工具.
- 现有的方法可能缺乏网络可视化和分析的用户友好性.
研究的目的:
- 开发一个用户友好的工具,AOP-networkFinder,用于检索,生成,清理和可视化AOP网络.
- 为了促进对AOPs中关键事件 (KE) 之间的复杂关系的理解.
- 支持研究人员根据FAIR原则建立和分析AOP网络.
主要方法:
- AOP-networkFinder工具使用其 SPARQL 终端从 AOP-Wiki 获取 AOP.
- 它通过连接基于共享关键事件 (KE) 的AOP来构建AOP网络.
- 该工具可视化这些网络,包括相关的基因,并允许将其导出到诸如Cytoscape.
主要成果:
- AOP-networkFinder可以有效地检索和可视化AOP网络.
- 该工具有助于识别KE和AOP整体结构之间的关系.
- 生成的网络可以导出用于进一步分析和微调,提高数据的可重复使用性.
结论:
- AOP-networkFinder为可视化和分析AOP网络提供了一个有价值的解决方案.
- 该工具增强对毒理途径的理解,并支持数据驱动的研究.
- 它的开源性质和可用性促进了计算毒理学的可访问性和协作.
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