美国人体形状指数与结直肠癌之间的关联:基于NHANES的横截面研究
Hui Liu1, Jialu Kang2, Wei Liu1
1Department of Internal Medicine Nursing, Faculty of Nursing, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China.
Frontiers in nutrition
|February 19, 2025
概括
腹部体形指数 (ABSI) 的升高与美国成年人患结肠直肠癌 (CRC) 的风险更高有关. 这种简单的人类测量方法对预测CRC发病率充满希望,特别是在特定的年龄和BMI群体.
科学领域:
- 肥胖和癌症流行病学
- 人类测量和健康风险评估
- 公共卫生和预防医学
背景情况:
- 大肠直肠癌 (CRC) 的发病率与肥胖有关,特别是内脏脂肪.
- 腹部身体形状指数 (ABSI) 提供了精细的内脏脂肪积累量度.
- 关于ABSI的跨民族适用性和CRC相关性的证据有限.
研究的目的:
- 调查腹部身体形状指数 (ABSI) 和结肠直肠癌 (CRC) 风险在美国人口中存在的关联.
- 探索ABSI对不同人口和人类学子组的CRC发病率的预测能力.
- 评估ABSI作为潜在的结直肠癌风险查工具.
主要方法:
- 从国家健康和营养检查调查 (NHANES) (2003-2023) 中对40,998名个人进行分析.
- 逻辑回归和受限立方线 (RCS) 曲线用于评估ABSI-CRC关联和非线性.
- 亚组分析,相互作用测试和接收器运行特征 (ROC) 曲线分析以评估预测性性能.
主要成果:
- 在共变量调整后,观察到ABSI和CRC发病率 (OR=1.03,P=0.018) 之间存在正相关性.
- 在最高的ABSI四分位数中的个体具有显著更高的CRC患病率 (OR=1.88,P=0.006).
- 确定了ABSI和CRC之间的非线性相关性 (P=0.030),在年龄和BMI子组中有显著的相互作用. ABSI显示出良好的预测值 (AUC=0.658),特别是在60岁以下的个体中.
结论:
- 更高的腹部身体形状指数 (ABSI) 水平与美国成年人结肠直肠癌 (CRC) 发病率的增加有关.
- ABSI证明了作为CRC风险的简单人体测量预测器的有效性,特别是在年轻人和特定的BMI类别中.
- 这些发现支持ABSI在识别患结直肠癌风险较高的个体中的实用性.
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