MONet:基于多omics数据和网络模型综合分析的癌症驱动基因识别算法
Yingzan Ren1, Tiantian Zhang1, Jian Liu1
1School of Mathematics and Statistics, Shandong University, Weihai, Shandong, China.
Experimental biology and medicine (Maywood, N.J.)
|February 19, 2025
概括
识别癌症驱动基因对于理解癌症至关重要. 一个新的算法,MONet,使用图形神经网络和多omics数据以高精度找到新的癌症驱动基因.
科学领域:
- 在瘤学瘤学.
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
背景情况:
- 癌症的进展是由特定基因的突变驱动的,称为驱动基因.
- 识别这些驱动基因对于开发向疗法和生物标志物至关重要.
- 由于数据的复杂性,目前的方法可能会错过关键的驱动基因.
研究的目的:
- 介绍MONet,一种用于识别癌症驱动基因的新算法.
- 为了利用多omics数据和网络分析进行增强的驱动基因检测.
- 为了发现以前未知的癌症驱动基因.
主要方法:
- 综合分析多领域数据和网络模型.
- 在蛋白质-蛋白质相互作用 (PPI) 网络上使用了两个图形神经网络算法.
- 采用多层感知子 (MLP) 模型进行半监督的驱动基因识别.
主要成果:
- MONet在各种PPI网络中表现出强性,并且表现优于基线模型.
- 在接收器操作特征曲线和精度回忆曲线下的区域中实现了卓越的性能.
- 确定了37个新的癌症驱动基因,其中29个在现有文献中得到验证 (例如,APOBEC2,GDNF,PRELP).
结论:
- MONet成功地确定了已知的和新的癌症驱动基因.
- 该算法为癌症机制提供了生物学上有意义的见解.
- MONet提高了潜在治疗点和生物标志物的发现.
更多相关视频
07:47Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
Published on: September 15, 2023
1.4K
07:41Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
8.8K
相关概念视频
02:02Genomics
35.7K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
35.7K
02:50Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K