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Updated: May 27, 2025

Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs
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向CDK4/6通过破坏YAP1的稳定性来抑制结直肠癌

Yalei Wen1,2, Xiao Yang2, Shengrong Li1,2

  • 1Research Institute for Maternal and Child Health, The Affiliated Guangdong Second Provincial General Hospital, Postdoctoral Research Station of Traditional Chinese Medicine, School of Pharmacy Jinan University Guangzhou China.

MedComm
|February 19, 2025
PubMed
概括

美国食品和药物管理局批准的药物Abemaciclib针对CDK4/6-DUB3途径降低YAP1,抑制结直肠癌 (CRC) 的进展. 这项研究揭示了针对CDK4/6减少YAP1稳定性的CRC的新治疗策略.

关键词:
是的相关蛋白1 (YAP1) 是的一个有着巨大的力量.大肠直肠癌 (CRC) 是一种癌症.循环林依赖性激酶4/6 (CDK4/6) 是一种杜比基化酶3 (DUB3) 是一种

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Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter11:32

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