由于Candida spppp引起的胃口穿孔.
Silvia Fernández Noël1, Julia Gutiérrez de Prado2, Óscar Caso Maestro2
1Cirugía General y del Aparato Digestivo, Hospital Universitario 12 de Octubre, España.
Revista espanola de enfermedades digestivas
|February 19, 2025
概括
肠道穿孔仍然很常见,即使在治疗Helicobacter pylori的情况下. 在这些穿孔中,Candida物种是相关的,这表明真菌共感染可能是围炎死亡的独立风险因素.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 手术病理学手术病理学
背景情况:
- 尽管有效的治疗Helicobacter pylori (HP),但肝孔发生率仍然存在.
- 这表明替代性或额外的病理机制有助于胃孔.
- 在这些情况下,真菌病原体,特别是Candida物种的作用需要进一步调查.
研究的目的:
- 为了调查Candida物种在 perforations的参与.
- 探索 perforations 在真菌 coinfection 的临床意义.
- 为了确定是否Candida共感染是围炎死亡的独立风险因素.
主要方法:
- 对患者数据和肝孔穿孔的临床结果的分析.
- 微生物学分析,包括腹培养和活检,以确定Candida spp.
- 统计分析以评估Candida共感染和死亡率之间的相关性.
主要成果:
- 这些发现支持Candida物种在孔中显著的相关性.
- 常规腹膜培养和活检被强调为重要的诊断工具.
- 菌共感染被提议作为围炎死亡的独立风险因素.
结论:
- 坎迪达菌种在肝孔中发挥作用,独立于Helicobacter pylori.
- 围液和组织的常规微生物学评估对于管理这些复杂病例至关重要.
- 考虑Candida共感染作为一个独立的死亡风险因素对于患者的管理和预后至关重要.
相关概念视频
01:22Esophageal Perforation-I: Introduction
56
Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
56
01:28Esophageal Perforation-II: Clinical Manifestations and Management
36
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
Clinical Manifestations:
36
01:30Peptic Ulcer Disease I: Introduction
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Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
119
01:28Peptic Ulcer Disease II: Pathophysiology
223
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
223
01:23Gastritis III: Clinical Manifestations and Management
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The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
124
01:22Pathophysiology of Peptic Ulcer Disease: Injurious Factors
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Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
524