空气污染与慢性乙型肝炎患者的死亡率相关,这些患者接受了核酸/核酸类似物治疗
Tyng-Yuan Jang1,2,3,4, Yu-Ting Zeng5, Po-Cheng Liang2,3
1Ph.D. Program in Environmental and Occupational Medicine, College of Medicine, Kaohsiung Medical University and National Health Research Institutes, Kaohsiung, Taiwan.
Alimentary pharmacology & therapeutics
|February 19, 2025
概括
空气污染,特别是氧化 (NOx),与正在接受治疗的慢性乙型肝炎 (CHB) 患者的死亡率增加有关. 对于肝硬化患者来说,这种风险更高,这表明对肝病结果的环境影响很大.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 环境健康 环境健康
- 公共卫生 公共卫生
背景情况:
- 空气污染是慢性肝病中晚期肝纤维化的一个已知的危险因素.
- 慢性乙型肝炎 (CHB) 患者接受核酸/核酸类似物治疗可能容易受到影响死亡率的环境因素的影响.
研究的目的:
- 研究接受核酸/核酸模拟治疗的CHB患者的空气污染暴露与全因死亡率之间的关联.
- 确定影响死亡风险的特定空气污染物和患者特征.
主要方法:
- 一组697名患有CHB的患者接受核酸/核酸类似物治疗,分析了死亡率和风险因素.
- 每日空气污染物度,包括氧化 (NOx),估计为患者入学前一年.
- 统计分析确定了与全因死亡率相关的因素,重点是肝硬化患者.
主要成果:
- 所有原因的死亡率发生在每年1.1/100人年的发病率.
- 关键的死亡预测因素包括肝硬化,年龄较大,以及治疗前高马-氨基转移酶 (GGT) 水平.
- 在肝硬化CHB患者中,高NOx度 (超过25.5ppb) 与所有原因死亡率的增加显著相关 (HR:2.49,p=0.04).
结论:
- 暴露于空气污染,特别是长期暴露于NOx,显著影响抗病毒治疗中CHB患者的全因死亡率.
- 在接受核酸/核酸模拟治疗的肝硬化CHB患者中,NOx暴露可能会加剧与肝脏相关的死亡风险.
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