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偏头痛,多发性硬化症前兆,以及多发性硬化症易感性
Vinicius A Schoeps1, Jessica B Smith2, Annette Langer-Gould3,4
1Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
偏头痛似乎是多发性硬化症 (MS) 发作的症状,而不是危险因素. 这项研究发现,偏头痛与多发性硬化症症状同时发生,这表明它们是疾病表现的一部分.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 以前的研究表明,偏头痛和多发性硬化症 (MS) 之间存在联系.
- 确切的关系,即偏头痛是否增加多发性硬化风险或是前兆症状,仍然不清楚.
研究的目的:
- 为了确定偏头痛是否先于或增加患MS的风险.
- 为了调查偏头痛发作和MS诊断之间的时间关系.
主要方法:
- 一个病例控制研究,涉及发生多发性硬化症 (MS) 病例和匹配的对照.
- 在结构化的采访中,收集了详细的头痛和MS病史.
- 偏头痛的诊断是基于国际头痛疾病分类标准;逻辑回归分析了关联.
主要成果:
- 偏头痛发作与MS发作同时或之前发生在21.2%的MS病例中,而对照组为18.7%.
- 在MS病例中 (14.4%) 与对照组 (6.6%) 相比,偏头痛同时发作或在MS症状发作前1年出现的可能性明显高.
- 当偏头痛发作严格在MS发作之前时,这种关联并不显著.
结论:
- 偏头痛与多发性硬化症的概率增加仅在偏头痛与多发性硬化症发病同时发生时.
- 研究结果表明,偏头痛是MS发病时症状综合体的一部分.
- 偏头痛不太可能是MS的风险因素或前兆症状.
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