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通过CD光谱学对蛋白质聚合物和粉样纤维的结构性表征指南

József Kardos1,2, Márton Péter Nyiri1, Éva Moussong1,3

  • 1Department of Biochemistry, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.

Protein science : a publication of the Protein Society
|February 19, 2025
PubMed
概括

循环二重化 (CD) 光谱学可以有效地分析蛋白质聚合物和粉样纤维. 这项研究提供了一项方案,以克服挑战,并改进结构分析,以了解退行性疾病.

关键词:
阿尔茨海默氏症的疾病是阿尔茨海默氏症.成为自己.粉样蛋白的形成粉样蛋白-βββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ循环二重化谱光学 循环二重化谱光学蛋白质聚合蛋白质的聚合物二次结构估计二次结构估计

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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