磁共振引导的聚焦超声波治疗基本震:一个单一中心的经验
Victor S Hvingelby1,2,3, Pernille Kjeldsen2,3, Bo Bergholt1
1Department of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark.
Movement disorders clinical practice
|February 19, 2025
概括
磁共振成像指导聚焦超声波 (MRgFUS) 有效治疗基本震,在丹麦患者中显示出显著的症状改善. 虽然副作用最初很常见,但随着时间的推移,它们会减少,尽管步态和平衡问题仍然存在.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 医疗成像医学成像
背景情况:
- 基本震是最常见的高动力运动障碍.
- 磁共振成像指导聚焦超声波 (MRgFUS) 是一项成熟的二线治疗选择.
研究的目的:
- 报告丹麦接受MRgFUS治疗的首批108名患者的结果.
- 评估MRgFUS对基本震的疗效和安全性.
主要方法:
- 在基线和治疗后3,6个月和12个月收集在质量保证数据库中的数据.
- 使用临床医生和患者等级尺度评估治疗疗效:Fahn-Marin-Tolosa (FMT) 和患者总体变化印象.
主要成果:
- 3个月后在FMT部分A,B和C观察到显著的震改善 (P < 0.00001对所有).
- 在3个月后,65.7%的患者报告了不良事件,在12个月后降至33.7%.
结论:
- 研究结果与对关键震的MRgFUS现有证据一致.
- 需要进一步调查关于步态和平衡相关副作用的长期持续性.
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