在对手的认知-动机风格中固有的皮层-状动作控制
Cassandra Avila1, Martin Sarter1,2
1Department of Psychology, University of Michigan, Ann Arbor, United States.
eLife
|February 19, 2025
概括
研究人员根据老鼠的注意力风格,在老鼠身上发现了不同的皮层-状控制机制. 目标追踪器显示出更严格的控制,而标志追踪器显示出更灵活的,在背中条体中由暗示驱动的谷氨酸释放.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 系统神经科学 系统神经科学
背景情况:
- 运动控制依赖于注意学习的线索来选择或抑制动作.
- 皮层-状突起对于大脑的注意力-运动界面至关重要.
- 认知-动机偏差的个体差异,比如目标跟踪与信号跟踪,影响行为.
研究的目的:
- 为了研究在小鼠的 cued 作用期间,在背中条体 (dorsomedial striatum,DMS) 中的谷氨酸动态.
- 为了确定前临床DMS预测对表达行为和谷氨酸释放的必要性.
- 为了比较目标追踪器 (GTs) 和标志追踪器 (STs) 之间的皮层-状管控制.
主要方法:
- 使用谷氨酸感应微电极阵列来测量大鼠DMS中的谷氨酸过渡物.
- 采用化学遗传抑制的前临床-DMS投射.
- 基于它们的注意力策略,以GT或ST的行为特征为特征的老鼠.
主要成果:
- GT开始转的速度较慢,但执行的转比ST多.
- 在转时,Cue引起的谷氨酸度在GT中高于ST.
- 在GT和ST中,抑制前临床DMS投影对转率和谷氨酸释放有不同的影响,这表明有不同的调节机制.
结论:
- 在GT中,转引发的谷氨酸释放受到皮层-状腺活动的严格调节.
- 在ST中,DMS中的谷氨酸释放可能涉及其他条状电路,可能与动作抑制和奖励跟踪有关.
- 皮层-状控制中的表型差异突出显示了个体对神经和精神疾病的脆弱性.
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