青提取物的亚急性毒性:大鼠的生化和病理学变化
N F AlAhmady1,2, M G Al-Mutary1,2, H A Alqahtani1,2
1Imam Abdulrahman Bin Faisal University, College of Science, Department of Biology, Dammam, Saudi Arabia.
Brazilian journal of biology = Revista brasleira de biologia
|February 19, 2025
概括
甲酸乙烯提取物Chrozophora tinctoria在老鼠中显示出亚急性毒性,导致器官异常和改变生物化学标记. 需要进一步的研究来评估其药用安全性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 民族植物学 民族植物学
背景情况:
- 药用植物需要严格的毒理学评估才能在传统和现代医学中安全使用.
- 克罗索福拉属,特别是克罗索福拉,用于医学上,在包括沙特阿拉伯在内的地区发现.
研究的目的:
- 在雄性和雌性大鼠中评估Chrozophora tinctoria乙烯酸提取物 (EtOAcE) 的亚急性毒性.
- 为了确定与Chrozophora tinctoria消费相关的潜在不良影响和安全问题.
主要方法:
- 鼠 (雄性和雌性) 每天服用50,100和200毫克/公斤的Chrozophora tinctoria EtOAcE,持续14天.
- 评估的参数包括死亡率,体重变化,器官重量,脏和肝功能测试,葡萄糖,皮质醇水平和组织病理学检查.
主要成果:
- 每组只有一只老鼠的死亡率. 雌性大鼠的体重减少;器官重量没有受到影响.
- 胆红素和肌素 (男性) 和尿酸 (女性) 的显著增加在200mg/kg时被观察到.
- 发现肝酶 (ALP,ALT,GGT) 和葡萄糖 (女性) 的升高. 组织病理学揭示了肝脏,脏,脏和小肠的异常.
结论:
- 酸乙提取物在老鼠中表现出亚急性毒性,影响生化标志物并导致组织病理损伤.
- 对于Chrozophora tinctoria的药用,必须进行仔细的评估和监测.
- 需要进一步的研究来确定其长期安全性和治疗指数.
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