代谢功能障碍和与酒精有关的肝病:叙述性审查
Nicholas Dunn1, Naim Al-Khouri2, Ismail Abdellatif3
1Department of Medicine, Kansas University Medical Center, Kansas City, Kansas, USA.
Clinical and translational gastroenterology
|February 19, 2025
概括
代谢和与酒精有关的肝病 (Met-ALD) 影响了美国的1700万人. 治疗包括改变生活方式和潜在的新药物,以获得更好的结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 与酒精有关的疾病与酒精有关的疾病
背景情况:
- 脂肪性肝病 (Steatotic liver disease,简称SLD) 涉及到脂肪在肝脏中积累的情况.
- SLD包括与代谢功能障碍相关的SLD (MASLD),与酒精相关的肝病 (ALD) 以及代谢和ALD (Met-ALD).
- 甲基ALD涉及心脏代谢风险因素和酒精消费.
研究的目的:
- 为了定义Met-ALD,一个独特的肝病.
- 突出Met-ALD.的独特风险和治疗方法.
- 讨论未来可能的Met-ALD治疗方法.
主要方法:
- 根据心脏代谢风险因素和男性和女性每周酒精消耗的具体标准定义Met-ALD.
- 根据酒精摄入门,区分Met-ALD与MASLD和ALD.
- 审查了当前和潜在的未来治疗策略.
主要成果:
- 据估计,Met-ALD在美国影响了大约1700万人.
- 这种情况与MASLD或ALD相比,存在肝硬化,肝细胞癌和死亡率的独特风险.
- 目前的治疗重点是减肥,戒酒,以及控制心脏代谢风险因素.
结论:
- 甲基-ALD是一种显著而独特的肝病实体.
- 有效的管理需要解决代谢和与酒精有关的因素.
- 新兴疗法,包括GLP-1激动剂和FGF21类似物,对Met-ALD治疗有希望.
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