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Updated: May 27, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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强大的p53表型和潜在的下游目标在以端粒酶不朽化的人类细胞中

Jessica J Miciak1,2, Lucy Petrova1, Rhythm Sajwan1

  • 1Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA.

Oncotarget
|February 19, 2025
PubMed
概括

在癌细胞中恢复野生型p53阻碍了癌细胞的增殖,并增加了对辐射的敏感性. 在正常细胞中研究p53揭示了像ALDH3A1和NECTIN4这样的新目标,这对于理解瘤抑制至关重要.

关键词:
这就是ALDH3A1A1的含量.尼克丁 (NECTIN) 是一种4不朽的细胞是不朽的细胞.电离辐射辐射的电离辐射.在 p53 里,p53 是一个 p53 的类型.

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