修改虚弱指数对甲状腺癌患者手术后恶心和吐的预测效果
Chengzhen Zhang1,2, Wenying Chi1, Xiaoqian Yu3
1Department of Anesthesiology, Central Hospital Affiliated to Shandong First Medical University, Shandong, PR China.
Medicine
|February 19, 2025
概括
通过修改的脆弱指数 (mFI) 测量的脆弱性是甲状腺癌患者手术后恶心和吐 (PONV) 的重要预测因素. 这一发现凸显了脆弱性是甲状腺手术后管理PONV的关键因素.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 麻醉学 麻醉学
背景情况:
- 手术后恶心和吐 (PONV) 是甲状腺癌手术后的频繁且显著的并发症.
- 脆弱性是不良术后结果的已知的危险因素,但其与甲状腺癌患者PONV的特定关联仍未得到充分探索.
研究的目的:
- 为了研究脆弱性和PONV发生率之间的相关性,在接受激进甲状腺癌手术的患者中.
- 确定PONV的独立风险因素,并开发一个预测模型.
主要方法:
- 对908名接受过甲状腺癌手术的患者进行了回顾性分析.
- 患者被分为PONV和非PONV组. 收集了有关一般和临床特征的数据.
- 采用了单变量和多变量逻辑回归,ROC曲线分析,以及具有评分系统的预测模型.
主要成果:
- 修改后的脆弱指数 (mFI) 显示出与PONV (系数=0.523) 最强的相关性.
- 已确定的独立风险因素包括年龄,阿佩尔得分,mFI得分,自由脂肪酸,尿酸,同氨酸 (HCY) 和禁食血糖.
- 预测模型显示了高的诊断效率,AUC为0.893.
结论:
- 修改的脆弱指数 (mFI) 是甲状腺癌手术后PONV的显著和强大的预测指标.
- 在手术前评估脆弱性可以帮助识别患有PONV风险较高的患者,从而实现有针对性的干预.
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