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Updated: May 27, 2025

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
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Published on: March 24, 2015

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PARP7 抑制I型干扰素信号传递,以预防自身免疫和肺部疾病

Devon Jeltema1, Kennady Knox1, Nicole Dobbs1

  • 1Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

The Journal of experimental medicine
|February 19, 2025
PubMed
概括

聚 ((ADP-ribose) 聚合酶7 (PARP7) 对I型干扰素 (IFN-I) 的产生产生产生负面调节. 在小鼠中失去PARP7会导致系统性自身免疫和肺炎,突出其在免疫恒温中的作用.

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